Tosylmethyl isocyanide → 1,7,7-Trimethyl-bicyclo[2.2.1]heptane-2-carbonitrile

HRID 1018346노트

반응식

HRID 1018346 반응식
[C@:1]12([CH3:11])[C:8]([CH3:10])([CH3:9])[CH:5]([CH2:6][CH2:7]1)[CH2:4][C:2]2=O.S([CH2:22][N+:23]#[C-])(C1C=CC(C)=CC=1)(=O)=O>>[CH3:11][C:1]12[C:8]([CH3:10])([CH3:9])[CH:5]([CH2:6][CH2:7]1)[CH2:4][CH:2]2[C:22]#[N:23]

참가 물질

3

반응물 2

HCID 161915Tosylmethyl isocyanideHCID 9543187Npc54264

생성물 1

HCID 184055501,7,7-Trimethyl-bicyclo[2.2.1]heptane-2-carbonitrile

실험 절차

(1R)-(+)-Camphor was converted to the nitrile using tosylmethyl isocyanide according to the procedure of O. H. Oldenziel (O. H. Oldenziel, D. van Leusen, and A. M. van Leusen J.Org.Chem. 1977, 42, 3114).

출처 및 근거

ORD 기록
ord-ab03afc53d47427c8a72abb2a6f741a2
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479531B1

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