Thionyl Chloride → HCID 12011185, 화합물

HRID 1018504노트

반응식

S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16]O>>[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16][Cl:3]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 12011184HCID 12011184, 화합물

생성물 1

HCID 12011185HCID 12011185, 화합물

반응 조건

온도: 50 °C

실험 절차

To 3 ml of thionyl chloride is added 2.39 g (9.5 mmol) of 1- (2-chlorobenzyl)-4,5 dimethyl-2-hydroxymethylimidazole. The mixture is heated at 50° C. for about 5 min., and the thionyl choride is evaporated in vacuo. The residue is then dissolved in 10 ml of dichloromethane, and subsequently evaporated in vacuo. This is repeated twice to give 1-(2-chlorobenzyl)-4,5-dimethyl-2-chloromethylimidazole (4) as a cream colored foam which is used without further purification.

후처리

customthe thionyl choride is evaporated in vacuo
dissolutionThe residue is then dissolved in 10 ml of dichloromethane
customsubsequently evaporated in vacuo

출처 및 근거

ORD 기록: ord-329cf04769e3468c870b7ce4572947e3
출처 데이터셋: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06482844B1

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