Borane → (3-Chloro-1,2-phenylene)dimethanol

HRID 1018867

반응식

HRID 1018867 반응식
B.[Cl:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]=1[C:12]([OH:14])=[O:13].FC1C(CO)=C(CO)C=CC=1>>[Cl:2][C:3]1[C:4]([CH2:12][OH:13])=[C:5]([CH2:6][OH:7])[CH:9]=[CH:10][CH:11]=1.[Cl:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]=1[C:12]([OH:14])=[O:13]

참가 물질

5

반응물 3

HCID 6331BoraneHCID 962543-Chlorophthalic acidHCID 18402162(3-Fluoro-1,2-phenylene)dimethanol

생성물 2

HCID 962543-Chlorophthalic acidHCID 17862674(3-Chloro-1,2-phenylene)dimethanol수율 97%

실험 절차

3-chloro-1,2-di-(hydroxymethyl) benzene was prepared in 97% yield via borane reduction of 3-Chlorophthalic acid in a manner similar to that was used for the preparation of 3-fluoro-1,2-di-(hydroxymethyl) benzene as described in Example 13, Step A. 3-Chlorophthalic acid was prepared from according to the literature procedure of Fertel, L. B. et al. J. Org. Chem. 1993, 58(1), 261-263.

출처 및 근거

ORD 기록
ord-aa21a73739e64ce2981fed2651312f6f
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06482951B2

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