4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid → 4-[3-(1-Methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid
반응식
[CH3:1][N:2]1[C:6]([CH2:7][CH:8]=[CH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[C:12]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH:11]=2)=[CH:5][N:4]=[CH:3]1.N1C(C/C=C/C2C=CC(C(O)=O)=C(C3C=CC(F)=CC=3)C=2)=CN=C1>>[CH3:1][N:2]1[C:6]([CH2:7][CH:8]=[CH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[C:12]([C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[CH:11]=2)=[CH:5][N:4]=[CH:3]1참가 물질
3
실험 절차
4-[3-(1-Methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid was prepared from methyl 4-[3-(1-methylimidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoate using a similar method to that described for 4-[(E)-3-(imidazol-5-yl)prop-1-en-1-yl]-2-(4-fluorophenyl)benzoic acid in Example 37.
출처 및 근거
- ORD 기록
- ord-e12dfe9f7c694da68536eb7f3db3f989