Sodium Iodide → HCID 18400042, 화합물

HRID 1019064노트

반응식

HRID 1019064 반응식
Cl[CH2:2][O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.[I-:22].[Na+]>CC(C)=O>[I:22][CH2:2][O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 22035697HCID 22035697, 화합물

생성물 1

HCID 18400042HCID 18400042, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of chloromethyl-4-(4-methoxybenzyloxy)benzoate (0.77 g, 2.5 mmole) in 15 ml dry acetone was added sodium iodide (1.87 g, 12.5 mmole) and the mixture was stirred overnight at room temperature. The mixture was evaporated under reduced pressure and extracted with ethyl actate/water. The organic phase was washed with a 5% sodium thiosulfate solution, dried with sodium sulfate and evaporated under reduced pressure. Yield 0.86 g=86%

후처리

  1. customThe mixture was evaporated under reduced pressure
  2. extractionextracted with ethyl actate/water
  3. washThe organic phase was washed with a 5% sodium thiosulfate solution
  4. dry with materialdried with sodium sulfate
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-4658e286624a409db20fb06b0e324aec
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06486183B1

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