HCID 178418361, 화합물 → HCID 178430523, 화합물
반응식
[C:1]([C:3]1[C:8]2[N:9]=[CH:10][NH:11][C:7]=2[C:6]([CH3:12])=[C:5]([N+:13]([O-])=O)[CH:4]=1)#[N:2].[H][H]>CO.[Pd]>[NH2:13][C:5]1[CH:4]=[C:3]([C:1]#[N:2])[C:8]2[N:9]=[CH:10][NH:11][C:7]=2[C:6]=1[CH3:12]참가 물질
5
실험 절차
A mixture of 7-cyano-4-methyl-5-nitrobenzimidazole (0.91 g, 4.5 mmol) and 10% palladium-on-carbon (100 mg) in methanol (200 mL) is treated with an atmosphere of hydrogen (1 atm, balloon) for 14 hours. The resulting mixture is filtered through Celite and rotary evaporated. The residue is purified by flash chromatography (silica gel, 95:5 ethyl acetate:methanol) to afford 5-amino-7-cyano-4-methylbenzimidazole.
후처리
- filtrationThe resulting mixture is filtered through Celite and rotary evaporated
- customThe residue is purified by flash chromatography (silica gel, 95:5 ethyl acetate:methanol)
출처 및 근거
- ORD 기록
- ord-8fea9ded25904dafb16cf66c47b89271
- 출처 데이터셋
- uspto-grants-2002_11
- 특허 번호
- US06486190B1
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