Sodium Iodide → Propanoic acid, 2-methyl-, 1-iodoethyl ester
반응식
Cl[CH:2]([O:4][C:5](=[O:9])[CH:6]([CH3:8])[CH3:7])[CH3:3].[Na+].[I-:11]>CC#N>[I:11][CH:2]([O:4][C:5](=[O:9])[CH:6]([CH3:8])[CH3:7])[CH3:3]참가 물질
4
실험 절차
To a solution of the chloro compound from Step 1 (2.6 g, 17.3 mmol) in CH3CN (20 mL) at r.t. was added NaI (2.85 g, 19 mmol). The flask was covered with Al foil and the reaction was stirred ON at r.t. The orange suspension was filtered and the filtrate was evaporated to dryness. The crude product was dissolved in Et2O/H2O and the organic phase was washed with aqueous sodium metabisulfite and brine. After drying (MgSO4), filtering, and removal of solvent, a pale brown oil (1.92 g) was obtained.
후처리
- filtrationThe orange suspension was filtered
- customthe filtrate was evaporated to dryness
- dissolutionThe crude product was dissolved in Et2O/H2O
- washthe organic phase was washed with aqueous sodium metabisulfite and brine
- dry with materialAfter drying (MgSO4)
- filtrationfiltering
- customremoval of solvent
출처 및 근거
- ORD 기록
- ord-94e4cba280d846c698823ff719093957
- 출처 데이터셋
- uspto-grants-2002_11
- 특허 번호
- US06486142B2
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