Methanol → methyl piperidine-1-carboxylate

HRID 1019355

반응식

HRID 1019355 반응식
[N:1]1([C:7]([O:9][CH2:10]C)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CO.C[O-].[Na+]>C1COCC1>[N:1]1([C:7]([O:9][CH3:10])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 887MethanolHCID 213991-Piperidinecarboxylic acid, ethyl esterHCID 10942334Sodium Methoxide

생성물 1

HCID 232666methyl piperidine-1-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Polymer-bound piperidinecarboxylic acid, ethyl ester resin (0.25 g, 0.283 mmol) was swollen with a solution of MeOH (1 ml) in THF (4 ml) in a QUICKFIT test-tube. After addition of sodium methoxide (0.28 ml, 0.028 mmol, 1M solution in MeOH) the resulting suspension was stirred overnight at reflux. The reaction suspension was cooled down to room temperature and the resin was washed using VACMASTER station with DCM (4×3 ml), MeOH (2×3 ml) and then dried under vacuum. FT-IR (2% w/w KBr disk): C=0 1736 cm−1 (ester); 163 cm−1 (amide).

후처리

  1. temperatureat reflux
  2. washthe resin was washed
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-4b3d8bc8afbd4dad84dbdd0dff1214b2
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06486354B1

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