Methanol → HCID 18399215, 화합물

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C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([C:30]3[CH:35]=[C:34]([O:36][CH3:37])[C:33]([O:38][CH3:39])=[C:32]([O:40][CH3:41])[CH:31]=3)=[C:14]([C:26]([O:28][CH3:29])=[O:27])[N:15]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[C:16]2=[O:19])=[CH:11][C:10]=1[O:42][CH3:43])C1C=CC=CC=1.CO>[C].[Pd].CN(C)C=O>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([C:30]3[CH:35]=[C:34]([O:36][CH3:37])[C:33]([O:38][CH3:39])=[C:32]([O:40][CH3:41])[CH:31]=3)=[C:14]([C:26]([O:28][CH3:29])=[O:27])[N:15]([N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[C:16]2=[O:19])=[CH:11][C:10]=1[O:42][CH3:43]

참가 물질

실험 절차

To the compound obtained in Example 1 (2.8 g) are added methanol (100 ml), dimethylformamide (100 ml) and palladium-carbon (100 mg), and the mixture is stirred under hydrogen atmosphere (1 atm) at room temperature for 1.5 hour. The catalyst is removed by filtration, and the filtrate is concentrated. The precipitated crystals are collected by filtration, and washed with diethyl ether to give 7-hydroxy-6-methoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (2.26 g) as listed in Table 1.