Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrrolidine → 4-Methoxy-5-nitro-2-(pyrrolidin-1-yl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 2-Chloro-4-methoxy-5-nitropyridine | HCID 44119673 | — |
| 생성물 | 4-Methoxy-5-nitro-2-(pyrrolidin-1-yl)pyridine | HCID 57431518 | 46.9% |
반응 단계
The method described in Stage 12.1 is followed, starting from 5.4 g (28.64 mmol) of 2-chloro-4-methoxy-5-nitropyridine (WO2003/080610) and 4.53 g (63 mmol) of pyrrolidine. The product obtained is, in this case, purified by chromatography on a silica column, eluting with a mixture of heptane and ethyl acetate. In this way we isolate 3 g of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08716272B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-13083dc02c234193accf934a72a1ac84 |
| 출처 메모 | uspto-grants-2014_05 |