Methylphenidate Hydrochloride → Dexmethylphenidate

HRID 1019622

반응식

HRID 1019622 반응식
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl.[OH-].[NH4+]>O>[CH3:1][O:2][C:3]([C@H:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C@@H:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:4]

참가 물질

4

반응물 2

HCID 9280Methylphenidate HydrochlorideHCID 14923Ammonium Hydroxide

생성물 1

HCID 154101Dexmethylphenidate수율 98%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a 200 mL beaker was charged 10.0 g (37.1 mmol) racemic-methylphenidate hydrochloride and 135 mL water. Ammonium hydroxide (3.40 g; 96.8 mmol) was then added to bring the pH to approximately 9 upon which an oily semi-solid formed. The product was extracted with three 100 mL portions of ethyl acetate, the combined organic layers were dried over sodium sulfate, filtered and concentrated under reduce pressure at 40° C. to provide 8.5 g of a clear, colorless viscous oil (98% yield). The free base was characterized by FTIR and found to be consistent with the anticipated structure

후처리

  1. customformed
  2. extractionThe product was extracted with three 100 mL portions of ethyl acetate
  3. dry with materialthe combined organic layers were dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customat 40° C.

출처 및 근거

ORD 기록
ord-a418bcd7d433412c836dc3aef8829606
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716278B1

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