Sodium Azide → 3-Azido-N-methylpropane-1-sulfonamide

HRID 1019839

반응식

HRID 1019839 반응식
Cl[CH2:2][CH2:3][CH2:4][S:5]([NH:8][CH3:9])(=[O:7])=[O:6].[N-:10]=[N+:11]=[N-:12].[Na+]>CN(C=O)C.[Cl-].[Na+].O>[N:10]([CH2:2][CH2:3][CH2:4][S:5]([NH:8][CH3:9])(=[O:7])=[O:6])=[N+:11]=[N-:12]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 102412533-chloro-N-methylpropane-1-sulfonamide

생성물 1

HCID 866765133-Azido-N-methylpropane-1-sulfonamide수율 81%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 57417360Sodium chloride; water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 3-chloro-N-methylpropane-1-sulfonamide (29 mmol), NaN3 (29 mmol) in DMF (50 ml) was stirred at 100° C. for 2 h. The mixture was poured into 40 ml of brine. The mixture was extracted with ether (3×30 ml). The organic layers were combined and washed with 20 ml of brine. The organic layer was dried with Na2SO4, filtered and the filtrate was evaporated. Yield: 4.2 g (90% purity, 81% yield).

후처리

  1. extractionThe mixture was extracted with ether (3×30 ml)
  2. washwashed with 20 ml of brine
  3. dry with materialThe organic layer was dried with Na2SO4
  4. filtrationfiltered
  5. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-7327b5353c674b6295c48d1cd2618630
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716293B2

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