Trifluoroacetic acid → HCID 178487965, 화합물

HRID 1019861노트

반응식

HRID 1019861 반응식
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][C@H:15]1[CH2:20][CH2:19][C@H:18]([CH2:21][CH2:22][O:23][C:24]2[CH:25]=[N:26][C:27]3[C:32]([CH:33]=2)=[N:31][C:30]([O:34][CH3:35])=[CH:29][CH:28]=3)[CH2:17][CH2:16]1)(C)(C)C>ClCCl>[CH3:35][O:34][C:30]1[N:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[N:26]=[CH:25][C:24]([O:23][CH2:22][CH2:21][C@H:18]1[CH2:17][CH2:16][C@H:15]([NH2:14])[CH2:20][CH2:19]1)=[CH:33]2

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 178487968HCID 178487968, 화합물

생성물 1

HCID 178487965HCID 178487965, 화합물수율 100.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (6.33 mL, 82.2 mmol, 20 eq) is added at room temperature to a stirred solution of {trans-4-[2-(6-methoxy-[1,5]naphthyridin-3-yloxy)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester (1.65 g, 4.11 mmol, 1.0 eq) in dichloromethane (100 mL). After 2 hours stirring at room temperature, the reaction mixture is partitioned between saturated sodium hydrogen carbonate aqueous solution and dichloromethane and the pH value is about 10. The combined organic layers are dried over sodium sulfate and concentrated to afford trans-4-[2-(6-methoxy-[1,5]naphthyridin-3-yloxy)-ethyl]-cyclohexylamine as a yellow solid (1.24 g, 95% yield).

후처리

  1. customthe reaction mixture is partitioned between saturated sodium hydrogen carbonate aqueous solution and dichloromethane
  2. dry with materialThe combined organic layers are dried over sodium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c527e3fa967446a7a06fd5ba8fc6a3ef
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716280B2

반응 노트

불러오는 중…