반응식
CCOC(=O)c1cc2cccc(Br)c2o1.c1ccc(CCN2CCNCC2)nc1>C1COCCO1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>CCOC(=O)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1참가 물질
반응물 2
생성물 1
시약·촉매·용매 4
반응 조건
- 온도
- 95 °C
실험 절차
17/02 2009 12:47:13 +0100 To ethyl 7-bromobenzofuran-2-carboxylate (1.50 g, 5.57 mmol) and 1-(2-(pyridin-2-yl)ethyl)piperazine (1.120 g, 5.85 mmol) in dry degassed dioxane (20 mL) were added Cesium carbonate (2.361 g, 7.25 mmol), 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (0.266 g, 0.56 mmol) and Tris(dibenzylideneacetone)dipalladium(0) (0.255 g, 0.28 mmol) under argon and the reaction heated at 95°C o/n. The reaction was allowed to reach rt. Starting material left 18/02 2009 14:51:20 +0100 Additional2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (0.266 g, 0.56 mmol) and Tris(dibenzylideneacetone)dipalladium(0) (0.255 g, 0.28 mmol) were added and the reaction stirred at 95°C o/n. The reaction mixture was pooled with the reaction mixture in EN02198-44. Water and DCM were added and the layers separated. The aq phase was extracted with DCM (3x). The combined org phases were washed with water, dried (Na2SO4), filtered and evaporated. The crude was purified by flash chrom. (SiO2; DCM/MeOH 95/5) to give 1.48 g (35% calculated from EN02198-44+45) of the product as a pale brown solid.
출처 및 근거
- ORD 기록
- ord-3e4ae9ef9d2f47b2b03f41aafafa9bc4
- 출처 데이터셋
- 750 AstraZeneca ELN dataset
- 원본 링크
- 출처 보기
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