참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Chloroethyl formate | HCID 246748 | — |
| 반응물 | 6-(2-Methoxyphenyl)pyrimidin-4-amine | HCID 49758439 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | [6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-carbamic acid ethyl ester | HCID 59509103 | 44.8% |
반응 단계
To a mixture of 6-(2-methoxy-phenyl)-pyrimidin-4-ylamine (XXIV) (1.0 g, 4.9 mmol) and potassium carbonate (4.0 g, 29 mmol) in 2-butanone (10 ml), chloroethylformate (0.50 ml, 4.9 mmol) was added and the mixture was refluxed for 3 hours at 80° C. The reaction was monitored by TLC. After completion of the reaction, water was added and the mixture was extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated to provide 0.60 g of [6-(2-methoxy-phenyl)-pyrimidin-4-yl]-carbamic acid ethyl ester (XL).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08716296B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_05 |
|---|
| ORD ID | ord-df3a111454854ef9aba1f62402650947 |
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| 출처 메모 | uspto-grants-2014_05 |
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