Benzophenone imine → Methyl 3-(diphenylmethyleneamino)-2-phenylpropanoate

HRID 1020133노트

반응식

HRID 1020133 반응식
Cl.[NH2:2][CH2:3][CH:4]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:5]([O:7][CH3:8])=[O:6].[C:15](=N)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(Cl)Cl>[C:16]1([C:15](=[N:2][CH2:3][CH:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([O:7][CH3:8])=[O:6])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 136809Benzophenone imineHCID 42614489Methyl 3-amino-2-phenylpropanoate hydrochloride

생성물 1

HCID 59563738Methyl 3-(diphenylmethyleneamino)-2-phenylpropanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To methyl 3-amino-2-phenylpropanoate hydrochloride in CH2Cl2 was added benzophenone imine, and the solution was stirred overnight at room temperature. The mixture was then washed with H2O and the organics were dried (Na2SO4), filtered, and evaporated. Column chromatography (SiO2, 5-20% EtOAc/Hexanes) gave pure methyl 3-(diphenylmethyleneamino)-2-phenylpropanoate (E320).

후처리

  1. washThe mixture was then washed with H2O
  2. dry with materialthe organics were dried (Na2SO4)
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-83cb7884b8a745ea9da24785b0f97e41
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716310B2

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