Sodium Iodide → HCID 58055059, 화합물

HRID 1020252노트

반응식

HRID 1020252 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=1)=[O:8].[Na+].[I-:22]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][I:22])[N:14]=1)=[O:8]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 58055096HCID 58055096, 화합물

생성물 1

HCID 58055059HCID 58055059, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea (1 eq) in acetone was added NaI (10 eq) at once. The mixture was stirred at room temperature for 2 h. The volatiles were removed in vacuo and the mixture was taken up in water and EtOAc. The layers were separated and the organic phase was partitioned with water and then brine, dried over Na2SO4, filtered, and concentrated in vacuo to afford 1-(3,4-dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea as a tan-colored solid in near quantitative yield.

후처리

  1. customThe volatiles were removed in vacuo
  2. customThe layers were separated
  3. customthe organic phase was partitioned with water
  4. dry with materialbrine, dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8c1b86b5c80a4221ad823633a1a6d3f4
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716320B2

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