Methylamine → N,3-Dimethylpyrazin-2-amine

HRID 1020267노트

반응식

HRID 1020267 반응식
Cl[C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 66769Pyrazine, 2-chloro-3-methyl-

생성물 1

HCID 44327445N,3-Dimethylpyrazin-2-amine

실험 절차

2-chloro-3-methylpyrazine (124 mg, 1.0 mmol) and methylamine (5 mL, 2M solution in THF) was irradiated in a microwave oven at 190° C. for 10 hours. The solution is evaporated and the residue was dissolved in CH2Cl2 (10 mL). It was partitioned with NaOH (1 mL, 5N), dried with NaSO4, filtered and volatiles removed in vacuo to afford N,3-dimethylpyrazin-2-amine. 1H NMR (400 MHz, CDCl3): 7.92 (d, 1H), 7.70 (d, 1H), 4.40 (s, br, 1H), 3.03 (d, 3H), 2.36 (s, 3H). MS (ES+): M/Z 124 (M+1).

후처리

  1. customThe solution is evaporated
  2. dissolutionthe residue was dissolved in CH2Cl2 (10 mL)
  3. customIt was partitioned with NaOH (1 mL, 5N)
  4. dry with materialdried with NaSO4
  5. filtrationfiltered
  6. customvolatiles removed in vacuo

출처 및 근거

ORD 기록
ord-a62f1954fc154409a7c090afa8830d36
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716320B2

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