4-chloropyridine N-oxide → 4-((5-Fluoropyridin-2-yl)methoxy)pyridine 1-oxide

HRID 1020583

반응식

HRID 1020583 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:15])C2C=CC=CC=2)=[N:6][CH:7]=1.Cl[C:17]1[CH:22]=[CH:21][N+:20]([O-:23])=[CH:19][CH:18]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][O:15][C:17]2[CH:22]=[CH:21][N+:20]([O-:23])=[CH:19][CH:18]=2)=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 707244-chloropyridine N-oxideHCID 666033725-Fluoro-2-pyridylbenzylalcohol

생성물 1

HCID 580922634-((5-Fluoropyridin-2-yl)methoxy)pyridine 1-oxide수율 50.9%

실험 절차

5-Fluoro-2-pyridylbenzylalcohol (3.00 g, 23.6 mmol) and 4-chloropyridine-N-oxide (2.03 g, 15.7 mmol) were reacted according to Example 34 (step a) to provide the title compound (1.76 g, 50%) as a tan solid: 1H NMR (300 MHz, CDCl3) δ 8.48 (s, 1H), 8.12 (d, J=7.7 Hz, 2H), 7.48-7.46 (m, 2H), 6.90 (d, J=7.7 Hz, 2H), 5.20 (s, 2H).

출처 및 근거

ORD 기록
ord-8c95283acb4d48f783192ee0bc5c605e
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716308B2

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