Formic Acid → 3-(5-bromo-thiophen-2-yl)-1-methyl-1H-[1,2,4]triazole

HRID 1020954노트

반응식

HRID 1020954 반응식
[CH3:1][NH:2][NH:3][C:4]([C:6]1[S:7][C:8]([Br:11])=[CH:9][CH:10]=1)=[NH:5].[CH:12](O)=O>>[Br:11][C:8]1[S:7][C:6]([C:4]2[N:5]=[CH:1][N:2]([CH3:12])[N:3]=2)=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 178486232HCID 178486232, 화합물

생성물 1

HCID 583719633-(5-bromo-thiophen-2-yl)-1-methyl-1H-[1,2,4]triazole

실험 절차

A mixture of compound 5-bromo-thiophene 2-carboximidic-N′-methyl-hydrazide (4BW) (13 g) in formic acid (100 ml) was refluxed overnight and concentrated. The residue was treated with sat. NaHCO3, and extracted with EtOAc three times. The combined organics were dried over MgSO4. After concentration, compound 5BW was purified by column using 80% EtoAc/hexane to yield light yellow colored solid.

후처리

  1. temperaturewas refluxed overnight
  2. concentrationconcentrated
  3. additionThe residue was treated with sat. NaHCO3
  4. extractionextracted with EtOAc three times
  5. dry with materialThe combined organics were dried over MgSO4
  6. concentrationAfter concentration, compound
  7. customwas purified by column
  8. customto yield light yellow colored solid

출처 및 근거

ORD 기록
ord-88744a2cbbf34795ae70be31c1465d12
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716483B2

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