1,4-Dioxane → Methyl 6-chloronicotinimidate

HRID 1020958노트

반응식

HRID 1020958 반응식
C[O-].[Na+].[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[N:12])=[CH:7][N:6]=1.[O:13]1CCOC[CH2:14]1>CO.CCOC(C)=O.O>[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[NH:12])[O:13][CH3:14])=[CH:7][N:6]=1

참가 물질

7

반응물 3

HCID 312751,4-DioxaneHCID 51520946-Chloro-3-pyridinecarbonitrileHCID 10942334Sodium Methoxide

생성물 1

HCID 86762380Methyl 6-chloronicotinimidate

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

Sodium methoxide (725 mg, 13.42 mmol) was added to a solution of 2-Chloro pyridine-5-carbonitrile (1.8 g, 13.04 mmol) in MeOH:dioxane (40 ml, 1:1) at 0° C., then stirred for 30 minutes at 0° C., and 1 hour at room temperature. The reaction was diluted with EtOAc (200 ml) and H2O (100 ml), organic layer separated, dried over Na2SO4, filtered and solvent evaporated to yield title compound 1BX as a white solid (2.6 g, 100%) MS (MH 171)

후처리

  1. custom1 hour
  2. customat room temperature
  3. customseparated
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customsolvent evaporated

출처 및 근거

ORD 기록
ord-3615d29780be4a3081082198416b1932
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716483B2

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