Ethanol → Ethyl 2-fluoro-3-methylbenzoate

HRID 1021248노트

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HRID 1021248 반응식
[F:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:17][CH2:18]O>>[F:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:17][CH3:18])=[O:5]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 27373792-Fluoro-3-methylbenzoic acid

생성물 1

HCID 46311374Ethyl 2-fluoro-3-methylbenzoate

반응 조건

온도
90 °C

실험 절차

2-Fluoro-3-methylbenzoic acid (8.0 g) was mixed with EtOH (100 ml), and concentrated sulfuric acid was added thereto, followed by stirring at 90° C. overnight. The reaction mixture was concentrated under reduced pressure, and EtOAc and water were then added thereto. The organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution, then dried over Na2SO4, and concentrated under reduced pressure to obtain ethyl 2-fluoro-3-methylbenzoate (7.84 g).

후처리

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated under reduced pressure, and EtOAc and water
  3. additionwere then added
  4. washThe organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-71207a515886467c8efbd9f46606bb64
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716470B2

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