참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Trimethylsilylacetylene | HCID 66111 | — |
| 반응물 | 3-Bromo-2-fluorobenzyl Alcohol | HCID 26985646 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | {2-Fluoro-3-[(trimethylsilyl)ethynyl]phenyl}methanol | HCID 86686224 | — |
반응 단계
Under argon atmosphere, ethynyl(trimethyl)silane (9.0 ml) was mixed with triethylamine (50 ml), and (3-bromo-2-fluorophenyl)methanol, bis(triphenylphosphine)palladium chloride (II) (1.54 g), and copper iodide (420 mg) were added thereto, followed by stirring at 90° C. overnight. The reaction mixture was cooled to room temperature, and EtOAc was added thereto, followed by filtering using Celite as a filtration adjuvant. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/EtOAc) to obtain {2-fluoro-3-[(trimethylsilyl)ethynyl]phenyl}methanol (4.88 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08716470B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_05 |
|---|
| ORD ID | ord-df3195c3b90844b58834d087b34f5f85 |
|---|
| 출처 메모 | uspto-grants-2014_05 |
|---|
