Trifluoroacetic acid → 2-(4-Chloro-phenyl)-2-methoxy-ethylamine

HRID 1021546노트

반응식

HRID 1021546 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:18][CH3:19])[CH2:9][NH:10]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([O:18][CH3:19])[CH2:9][NH2:10])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67080810HCID 67080810, 화합물

생성물 1

HCID 532762402-(4-Chloro-phenyl)-2-methoxy-ethylamine수율 84.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl 2-(4-chlorophenyl)-2-methoxyethylcarbamate (0.129 g, 0.451 mmol) in dichloromethane (5 ml) was added trifluoroacetic acid (5 ml), and the reaction was stirred at ambient temperature for 16 hours. The reaction was concentrated and taken up in water. Sodium hydroxide (1M) was added until the pH was >13. The mixture was extracted twice with dichloromethane, and the combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated to yield 71 mg of the title compound (84.7% yield).

후처리

  1. concentrationThe reaction was concentrated
  2. additionSodium hydroxide (1M) was added until the pH was >13
  3. extractionThe mixture was extracted twice with dichloromethane
  4. dry with materialthe combined organic layers were dried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-146b2d051d4240efb0d695b8acd43309
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716498B2

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