(2-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methyl acetate → (4-(5-(5-(4-(2-Hydroxy-2-methylpropyl)piperazin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)pyridin-3-yl)methyl acetate

반응식

[C:1]([O:4][CH2:5][C:6]1[C:7]([N:29]2[CH2:41][CH2:40][N:32]3[C:33]4[CH2:34][CH2:35][CH2:36][CH2:37][C:38]=4[CH:39]=[C:31]3[C:30]2=[O:42])=[N:8][CH:9]=[CH:10][C:11]=1[C:12]1[CH:17]=[C:16]([NH:18][C:19]2[CH:23]=C(C3CC3)N[N:20]=2)[C:15](=[O:27])[N:14]([CH3:28])[CH:13]=1)(=[O:3])[CH3:2].BrC1C=C(NC2C=[CH:57][C:56]([N:59]3[CH2:64][CH2:63][N:62]([CH2:65][C:66]([OH:69])([CH3:68])[CH3:67])[CH2:61][CH2:60]3)=[CH:55]N=2)C(=O)N(C)C=1.C(OCC1C(N2CCN3C4CCCCC=4C=C3C2=O)=NC=CC=1B1OC(C)(C)C(C)(C)O1)(=O)C>>[C:1]([O:4][CH2:5][C:6]1[C:7]([N:29]2[CH2:41][CH2:40][N:32]3[C:33]4[CH2:34][CH2:35][CH2:36][CH2:37][C:38]=4[CH:39]=[C:31]3[C:30]2=[O:42])=[N:8][CH:9]=[CH:10][C:11]=1[C:12]1[CH:17]=[C:16]([NH:18][C:19]2[CH:23]=[CH:55][C:56]([N:59]3[CH2:64][CH2:63][N:62]([CH2:65][C:66]([OH:69])([CH3:67])[CH3:68])[CH2:61][CH2:60]3)=[CH:57][N:20]=2)[C:15](=[O:27])[N:14]([CH3:28])[CH:13]=1)(=[O:3])[CH3:2]