3,5-Dibromo-1-methylpyridin-2(1H)-one → 5-Bromo-1-methyl-3-(1-methyl-1H-1,2,3-triazol-4-ylamino)pyridin-2(1H)-one

반응식

[CH3:1][N:2]1[CH:6]=[C:5]([NH2:7])[N:4]=[N:3]1.Br[C:9]1[C:10](=[O:17])[N:11]([CH3:16])[CH:12]=[C:13]([Br:15])[CH:14]=1>>[Br:15][C:13]1[CH:14]=[C:9]([NH:7][C:5]2[N:4]=[N:3][N:2]([CH3:1])[CH:6]=2)[C:10](=[O:17])[N:11]([CH3:16])[CH:12]=1

참가 물질

반응물 2

HCID 36143503,5-Dibromo-1-methylpyridin-2(1H)-one

HCID 145364341-methyl-1H-1,2,3-triazol-4-amine

생성물 1

HCID 866840445-Bromo-1-methyl-3-(1-methyl-1H-1,2,3-triazol-4-ylamino)pyridin-2(1H)-one수율 52.5%

실험 절차

Following the procedure in Example 130c, and starting with 293b (500 mg, 5.10 mmol, 1.0 eq.) and 3,5-dibromo-1-methylpyridin-2(1H)-one (2.04 g, 7.65 mmol, 1.5 eq.) afforded 293c as a yellow solid (760 mg, 52%). MS-ESI: [M+H]+ 283.9.

출처 및 근거

ORD 기록: ord-315e676635484d4d9686fcb83035fd30
출처 데이터셋: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08716274B2

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