3,5-Dibromo-1-methylpyridin-2(1H)-one → HCID 86684615, 화합물

HRID 1022260노트

반응식

HRID 1022260 반응식
[NH2:1][C:2]1[CH:14]=[C:5]2[CH2:6][N:7]([CH2:10][CH2:11][C:12]#[N:13])[CH2:8][CH2:9][N:4]2[N:3]=1.Br[C:16]1[C:17](=[O:24])[N:18]([CH3:23])[CH:19]=[C:20]([Br:22])[CH:21]=1>>[Br:22][C:20]1[CH:21]=[C:16]([NH:1][C:2]2[CH:14]=[C:5]3[CH2:6][N:7]([CH2:10][CH2:11][C:12]#[N:13])[CH2:8][CH2:9][N:4]3[N:3]=2)[C:17](=[O:24])[N:18]([CH3:23])[CH:19]=1

참가 물질

3

반응물 2

HCID 36143503,5-Dibromo-1-methylpyridin-2(1H)-oneHCID 866846163-(2-Amino-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)propanenitrile

생성물 1

HCID 86684615HCID 86684615, 화합물수율 63.1%

실험 절차

Following the procedure of Example 309c, and starting with 338b (120 mg, 0.63 mmol) and 3,5-dibromo-1-methylpyridin-2(1H)-one (169 mg, 0.63 mmol) afforded 338c as a yellow solid (150 mg, 63%). MS-ESI: [M+H]+ 377.2

출처 및 근거

ORD 기록
ord-741166c2576e4d2db5e74de41bdb6610
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716274B2

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