참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 1-Methoxypiperidin-4-one | HCID 19936653 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ammonium Hydroxide | HCID 14923 | — |
| 생성물 | 4-Amino-1-methoxy-piperidine-4-carbonitrile | HCID 59614594 | 68.7% |
반응 단계
To 10 g of N-methoxy-4-piperidone (J. Org. Chem. 1961, 26, 1867-74) in 240 ml ammoniumhydroxide 25% in water there are added 6.2 g of ammoniumchloride and 4.6 g of sodium cyanide. After stirring for 18 h at 25° C. the reaction mixture is diluted with 200 ml water and extracted with ethyl acetate. The organic phase is separated, dried over sodium sulphate, filtered and evaporated. 8.25 g of 4-amino-1-methoxy-piperidine-4-carbonitrile is obtained as light brow oil, which is used without further purification in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08722578B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_05 |
|---|
| ORD ID | ord-f4e338df5ee04a02bd6e4dab3868329c |
|---|
| 출처 메모 | uspto-grants-2014_05 |
|---|
