Furfurylamine → HCID 9291888, 화합물

HRID 1022408노트

반응식

HRID 1022408 반응식
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:18])[CH:8]=2)[N:3]=1.[CH2:19]([NH2:25])[C:20]1[O:24][CH:23]=[CH:22][CH:21]=1>O>[Cl:18][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:25][CH2:19][C:20]1[O:24][CH:23]=[CH:22][CH:21]=1)[N:11]=[C:10]2[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 3438FurfurylamineHCID 16282212,6-dichloro-4-phenylquinazoline

생성물 1

HCID 9291888HCID 9291888, 화합물수율 83.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 275 mg of 2,6-dichloro-4-phenylquinazoline (compound No. II-2) and 486 mg of furfurylamine was stirred at 85° C. for 40 minutes and then poured into 50 ml of water. The mixture was extracted with ethyl acetate, and the resultant extract was washed with water and then concentrated. The resulting residue was recrystallized from ethanol to obtain 280 mg of the titled compound. Mp.142.0° C. 1H NMR (CDCl3): 4.77 (2H, d, J=5.6 Hz), 5.70 (1H, br. t, J=5.6 Hz), 6.29-6.32 (2H, m), 7.36 (1H, dd, J=1.8, 0.9 Hz), 7.53-7.70 (7H, m), 7.78 (1H, d, J=2.2 Hz).

후처리

  1. extractionThe mixture was extracted with ethyl acetate
  2. extractionthe resultant extract
  3. washwas washed with water
  4. concentrationconcentrated
  5. customThe resulting residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-a9eb6adb92564a628e189e39bb4a4f35
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722580B2

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