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6-acetyl-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-pyran-4-yl)-quinazoline-2,4(1H,3H)-dione → 3-(3,4-dimethoxybenzyl)-6-(1-hydroxy-1-methylethyl)-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione

HRID 1022496
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인쇄 미리보기

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HRID 1022496 반응식
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)[C:9](=[O:20])[N:8]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([O:30][CH3:31])[CH:23]=1)[C:7]2=[O:32])(=[O:3])[CH3:2].[CH3:33][Mg]I>CCOCC>[CH3:31][O:30][C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][C:25]=1[O:28][CH3:29])[CH2:21][N:8]1[C:7](=[O:32])[C:6]2[C:11](=[CH:12][CH:13]=[C:4]([C:1]([OH:3])([CH3:33])[CH3:2])[CH:5]=2)[N:10]([CH:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[C:9]1=[O:20]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 497644036-acetyl-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-pyran-4-yl)-quinazoline-2,4(1H,3H)-dioneHCID 178418373HCID 178418373, 화합물

생성물 1

HCID 497642843-(3,4-dimethoxybenzyl)-6-(1-hydroxy-1-methylethyl)-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione수율 9.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

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온도
0 °C

실험 절차

0.1 g of 6-acetyl-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione is added to a solution of 0.143 g of methylmagnesium iodide in 1 ml of Et2O. This mixture is stirred for 30 minutes at 0° C. and then overnight at room temperature. The reaction mixture is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with EtOAc to give 0.01 g of the expected product.

후처리

  1. customovernight
  2. customat room temperature
  3. customThe reaction mixture is evaporated under reduced pressure
  4. customThe residue is chromatographed on silica gel
  5. washeluting with EtOAc

출처 및 근거

ORD 기록
ord-03cf341822f3414ca147a2e0ea47c0dd
출처 데이터셋
uspto-grants-2014_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08722659B2

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