Trifluoroacetic acid → tert-Butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(2S)-1-(1,2-oxazinan-2-yl)-1-oxo-3,3-diphenylpropan-2-yl]amino}-3-oxopropyl]pyrrolidine-1-carboxylate

HRID 1022521노트

반응식

HRID 1022521 반응식
C(O[C:6](=[O:24])[NH:7][C@@H:8]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]([N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][O:12]1)=[O:10])(C)(C)C.[C:25]([O:29][C:30]([NH:32][C@H:33](C(O)=O)[CH:34]([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43]C=1)C1C=CC=CC=1)=[O:31])([CH3:28])([CH3:27])[CH3:26].FC(F)(F)[C:52](O)=[O:53].C(OC(N[C@H](C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(OC(C)(C)C)=O)=O)C(C)C)=O)[C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1>>[CH3:52][O:53][C@@H:45]([C@@H:46]1[CH2:41][CH2:34][CH2:33][N:32]1[C:30]([O:29][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:31])[C@@H:44]([CH3:43])[C:6]([NH:7][C@@H:8]([CH:17]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:58]1[CH:59]=[CH:60][CH:61]=[CH:62][CH:63]=1)[C:9]([N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][O:12]1)=[O:10])=[O:24]

참가 물질

5

반응물 4

HCID 6422Trifluoroacetic acidHCID 2761487Boc-L-3,3-DiphenylalanineHCID 10529182(3R,4S,5S)-tert-butyl 4-((S)-2-(((benzyloxy)carbonyl)amino)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoateHCID 89181604tert-Butyl[(2S)-1-(1,2-oxazinan-2-yl)-1-oxo-3-phenylpropan-2-yl]carbamate3회

생성물 1

HCID 89642541tert-Butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(2S)-1-(1,2-oxazinan-2-yl)-1-oxo-3,3-diphenylpropan-2-yl]amino}-3-oxopropyl]pyrrolidine-1-carboxylate

실험 절차

The title compound was prepared analogously to the synthesis of Intermediates 5 and 6 in three steps by coupling commercially available N-(tert-butoxycarbonyl)-β-phenyl-L-phenylalanine with 1,2-oxazinane hydrochloride (Starting Material 5), subsequent deprotection with trifluoroacetic acid and another coupling with Starting Material 1. The end product was purified by preparative HPLC.

후처리

  1. customThe end product was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-e9d9148abc214fbd923cf0ea36947272
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722629B2

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