3-{[(4-Fluorophenyl)sulfonyl]methyl}azetidine hydrochloride → HCID 21978404, 화합물

HRID 10227

반응식

HRID 10227 반응식
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH2:12][CH:13]2[CH2:16][NH:15][CH2:14]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[Br:17][C:18]1[S:26][C:21]2[S:22][C:23]([Br:25])=[CH:24][C:20]=2[C:19]=1[CH2:27]Br>>[Br:17][C:18]1[S:26][C:21]2[S:22][C:23]([Br:25])=[CH:24][C:20]=2[C:19]=1[CH2:27][N:15]1[CH2:16][CH:13]([CH2:12][S:9]([C:6]2[CH:7]=[CH:8][C:3]([F:2])=[CH:4][CH:5]=2)(=[O:11])=[O:10])[CH2:14]1

참가 물질

3

반응물 2

HCID 219783933-{[(4-Fluorophenyl)sulfonyl]methyl}azetidine hydrochlorideHCID 219784032,5-Dibromo-3-(bromomethyl)thieno[2,3-b]thiophene

생성물 1

HCID 21978404HCID 21978404, 화합물

실험 절차

Prepared from 3-{[(4-fluorophenyl)sulfonyl]methyl}azetidine hydrochloride (Example 1 Step 4) and 2,5-dibromo-3-(bromomethyl)thieno[2,3-b]thiophene (Step 3) according to the method of Example 1 Step 5. 1H NMR (500 MHz, CDCl3) δ 7.90–7.88 (2H, m), 7.33 (1H, s), 7.26–7.23 (2H, m), 3.60 (2H, s), 3.40 (2H, t, J=7.4 Hz), 3.35 (2H, d, J=7.3 Hz), 2.90 (2H, t, J=7.0 Hz), 2.84–2.77 (1H, m); m/z (ES+) 540 (M+H)+.

출처 및 근거

ORD 기록
ord-98db43d6f9f646978521d0f68346a642
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094777B2

연결된 노트

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