3-(Pyridin-2-yl)propanoic acid → N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(pyridin-2-yl)propanamide monohydrochloride

HRID 1022742

반응식

HRID 1022742 반응식
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][CH2:32][C:33](O)=[O:34]>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:33](=[O:34])[CH2:32][CH2:31][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][N:25]=2)=[CH:11][C:12]=1[F:17]

참가 물질

3

반응물 2

HCID 5642923-(Pyridin-2-yl)propanoic acidHCID 66975002HCID 66975002, 화합물

생성물 1

HCID 66976608N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(pyridin-2-yl)propanamide monohydrochloride

실험 절차

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 3-(pyridin-2-yl)propanoic acid, and by a method similar to that of Example 39, the title compound was obtained.

출처 및 근거

ORD 기록
ord-84e4f34e7f9840ddae85facd091dd078
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722662B2

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