Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron tribromide → 6-Hydroxy-4-(4,4,4-trifluoro-butyl)-isoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron tribromide | HCID 25134 | — |
| 반응물 | 6-Methoxy-4-(4,4,4-trifluoro-butyl)-isoquinoline | HCID 57647053 | — |
| 반응물 | 6-Isoquinolinol, 7-bromo- | HCID 135854837 | — |
| 생성물 | 6-Hydroxy-4-(4,4,4-trifluoro-butyl)-isoquinoline | HCID 136092899 | 42.4% |
반응 단계
1.02 g of 6-Methoxy-4-(4,4,4-trifluoro-butyl)-isoquinoline (87) were treated with boron tribromide as described for the synthesis of compound 1 to give 410 mg of the desired product 88. LCMS Method #1, retention time 1.04 min, detected mass 256.00 [M+H]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08722671B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-dd086d6d87324607b9f3a4aaf670a77a |
| 출처 메모 | uspto-grants-2014_05 |