[4-(2-Phenyl-2-o-tolyl-vinyl)-pyridin-2-yl]-urea → [4-(2-Phenyl-2-o-tolyl-ethyl)-pyridin-2-yl]-urea

HRID 1023439노트

반응식

HRID 1023439 반응식
[C:1]1([C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])=[CH:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([NH2:18])=[O:17])[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.C(Cl)Cl.[Pd]>[C:1]1([CH:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([NH2:18])=[O:17])[CH:10]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 2

HCID 69083977[4-(2-Phenyl-2-o-tolyl-vinyl)-pyridin-2-yl]-ureaHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 69675800[4-(2-Phenyl-2-o-tolyl-ethyl)-pyridin-2-yl]-urea수율 14%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

[4-(2-Phenyl-2-o-tolyl-vinyl)-pyridin-2-yl]-urea (140 mg, 0.43 mmol) is dissolved in methanol (2 mL) and DCM (2 mL). Then 5% palladium on carbon (90 mg, 0.043 mmol) is added. The reaction is stirred for 16 hours under the hydrogen atmosphere. The palladium on carbon is filtered and the filtrate is concentrated to give the crude product. Purification by Gilson preparative HPLC affords 20 mg of the titled product.

후처리

  1. filtrationThe palladium on carbon is filtered
  2. concentrationthe filtrate is concentrated
  3. customto give the crude product
  4. customPurification by Gilson preparative HPLC

출처 및 근거

ORD 기록
ord-d68d4513a52846dc93f7ff3d5378bc9d
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722709B2

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