Pyridine → HCID 67235281, 화합물

HRID 1023576노트

반응식

HRID 1023576 반응식
[CH3:1][C:2]1([CH3:9])[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[F:10][C:11]1[N:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1.N1C=CC=CC=1>ClCCl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[F:10][C:11]1[N:16]=[CH:15][C:14]([N:4]2[C:3](=[O:8])[C:2]([CH3:9])([CH3:1])[NH:6][C:5]2=[O:7])=[CH:13][CH:12]=1

참가 물질

6

반응물 3

HCID 1049PyridineHCID 6491DimethylhydantoinHCID 2783397(6-Fluoropyridin-3-yl)boronic acid

생성물 1

HCID 67235281HCID 67235281, 화합물수율 48.6%

시약·촉매·용매 2

HCID 8895Cupric acetate촉매HCID 6344Dichloromethane용매

실험 절차

Two reactions were set up in parallel. For each of them, to a solution of 5,5-dimethyl-2,4-imidazolidinedione (1.5 g, 11.71 mmol) in dry dichloromethane (100 mL), (6-fluoro-3-pyridinyl)boronic acid (1.980 g, 14.05 mmol), copper(II) acetate (2.126 g, 11.71 mmol) and pyridine (1.420 mL, 17.56 mmol) were added. The reaction was left under stirring under air atmosphere at room temperature overnight. The two reaction mixtures were combined and the solid was filtered off. The resulting solution was washed with water (90 mL). The aqueous phase was extracted twice with dichloromethane (twice 90 mL). The organic phases were combined and washed with brine and dried over anhydrous sodium sulphate. Removal of the solvent afforded a residue which was purified by silica gel chromatography (Biotage system, 100 g SNAP column) using as eluent a gradient and cyclohexane/ethyl acetate from 65/35 to 50/50 to afford the title compound as a white solid (1.27 g).

후처리

  1. waitThe reaction was left
  2. customThe two reaction mixtures
  3. filtrationthe solid was filtered off
  4. washThe resulting solution was washed with water (90 mL)
  5. extractionThe aqueous phase was extracted twice with dichloromethane (twice 90 mL)
  6. washwashed with brine
  7. dry with materialdried over anhydrous sodium sulphate
  8. customRemoval of the solvent
  9. customafforded a residue which
  10. customwas purified by silica gel chromatography (Biotage system, 100 g SNAP column)

출처 및 근거

ORD 기록
ord-a36cc69d0e71494faf2aa06c071e62ff
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722695B2

반응 노트

불러오는 중…