HCID 67235751, 화합물 → HCID 53241715, 화합물

반응식

CC(C1C=[C:6]([O:10]C2N=CC(NC(=O)[C@@H](C)N)=CC=2)C=CC=1)C.[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:25]=1[O:31][C:32]1[N:37]=[CH:36][C:35]([NH:38][C:39](=[O:43])[C@@H:40]([CH3:42])[NH2:41])=[CH:34][CH:33]=1>>[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:25]=1[O:31][C:32]1[N:37]=[CH:36][C:35]([N:38]2[C:39](=[O:43])[C@@H:40]([CH3:42])[NH:41][C:6]2=[O:10])=[CH:34][CH:33]=1

참가 물질

반응물 2

HCID 67235751HCID 67235751, 화합물

HCID 67236009HCID 67236009, 화합물2회

생성물 1

HCID 53241715HCID 53241715, 화합물

실험 절차

The title compound was made in a similar fashion to the preparation of Example 9 replacing N1-(6-{[3-(1-methylethyl)phenyl]oxy}-3-pyridinyl)-D-alaninamide with N1-{6-[(2,5-dimethylphenyl)oxy]-3-pyridinyl}-D-alaninamide (Intermediate 36, 48 mg) to afford the title compound as a yellow powder (31 mg).

출처 및 근거

ORD 기록: ord-d214eead9c7e451e97c63e2c4f7d471d
출처 데이터셋: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08722695B2

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