HCID 67235595, 화합물 → HCID 53241721, 화합물

반응식

CC(C1C=[C:6]([O:10]C2N=CC(NC(=O)[C@@H](C)N)=CC=2)C=CC=1)C.[CH3:23][C:24]1[C:29]([O:30][CH3:31])=[CH:28][CH:27]=[CH:26][C:25]=1[O:32][C:33]1[N:38]=[CH:37][C:36]([NH:39][C:40](=[O:44])[C@@H:41]([CH3:43])[NH2:42])=[CH:35][CH:34]=1>>[CH3:43][C@H:41]1[NH:42][C:6](=[O:10])[N:39]([C:36]2[CH:37]=[N:38][C:33]([O:32][C:25]3[CH:26]=[CH:27][CH:28]=[C:29]([O:30][CH3:31])[C:24]=3[CH3:23])=[CH:34][CH:35]=2)[C:40]1=[O:44]

참가 물질

반응물 2

HCID 67235595HCID 67235595, 화합물2회

HCID 67235751HCID 67235751, 화합물

생성물 1

HCID 53241721HCID 53241721, 화합물

실험 절차

The title compound was made in a similar fashion to the preparation of Example 9 replacing N1-(6-{[3-(1-methylethyl)phenyl]oxy}-3-pyridinyl)-D-alaninamide with N-(6-{[2-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-alaninamide (Intermediate 63, 200 mg) to afford the title compound (184 mg).

출처 및 근거

ORD 기록: ord-0a822bb7a1a34ffa83803f6d2eb6ab94
출처 데이터셋: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08722695B2

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