Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → Pyridine-4-amidine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 4-Cyanopyridine | HCID 7506 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Pyridine-4-amidine hydrochloride | HCID 2776844 | 93% |
반응 단계
To a solution of sodium (0.23 g) in methanol (40 ml) was added 4-cyanopyridine (10.62 g) at r.t. Stirring was continued for 6 h followed by the addition of ammoniumchloride (5.9 g) and stirring was continued for another 10 h. Then, diethylether (120 ml) was added and the precipitate was filtered off after 30 min and washed with diethylether (20 ml). The product was dried under high vacuum. 4-Amidino-pyridine hydrochloride (14.95 g) was obtained as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094781B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-eabe532b36c040a6b450ec034d5b8835 |
| 출처 메모 | uspto-grants-2006_08 |