HCID 86762399, 화합물 → HCID 67277260, 화합물

HRID 1023767노트

반응식

HRID 1023767 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=2[O:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=O)=[O:9]>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=2[O:19][CH2:20][C:21]([OH:23])=[O:22])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])=[O:9]

참가 물질

3

반응물 1

HCID 86762399HCID 86762399, 화합물

생성물 1

HCID 67277260HCID 67277260, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

후처리

  1. customThe solvent was removed in vacuo
  2. customthe mixture was azeotroped with toluene
  3. custompurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

출처 및 근거

ORD 기록
ord-0298e4be90344ed08c72028118908fee
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722741B2

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