Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → HCID 11582566, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-bromo-2-fluoro-N,N-bis(1-methylethyl)-benzamide | HCID 67277185 | — |
| 반응물 | (2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid | HCID 67277298 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | HCID 11582566 | HCID 11582566 | — |
반응 단계
The product of step c) (200 mg), the product of step d) (200 mg), Pd(dppf)Cl2 (60 mg), sodium carbonate (350 mg) and dioxan (5 ml) were charged to a flask and heated at reflux for 24 h, then cooled to room temp and filtered (hyflo). The filtrate was concentrated in vacuo, then purified by reverse phase HPLC to give the title compound. Yield 22 mg
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08722741B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-bad716b28a464e43be1db3d9c312457c |
| 출처 메모 | uspto-grants-2014_05 |