Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2-Methoxy-1-(4-methoxyphenoxy)-4-propylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Propylguaiacol | HCID 17739 | — |
| 반응물 | (4-Methoxyphenyl)boronic acid | HCID 201262 | — |
| 촉매 | Cupric acetate | HCID 8895 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Methoxy-1-(4-methoxyphenoxy)-4-propylbenzene | HCID 24786192 | — |
반응 단계
A mixture containing 2-methoxy-4-propylphenol (0.625 mmol; 100 μl), copper(II) acetate (0.625 mmol; 114 mg), 4-methoxyphenylboronic acid (1.25 mmol; 190 mg), triethylamine (3.12 mmol; 0.43 ml), some crushed molecular sieves 4 Å in dichloromethane (3 ml) was stirred at rt under air for 24 h. The residue is filtered with chloroform on Celite. The organic phase is washed with saturated NH4Cl, saturated NaHCO3 and brine. After drying (MgSO4), concentration and purification by preparative TLC on silica gel (ethyl acetate/cyclohexane—20/80), the title compound is collected as a colorless oil (70 mg; 0.26 mmol; 41%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08722746B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-70b6199f952a41498993e72a04618e1a |
| 출처 메모 | uspto-grants-2014_05 |