Water → 2,6-Difluoro-nicotinic acid methyl ester
반응식
[F:1][C:2]1[N:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.O.[C:18](=O)([O-])[O-].[K+].[K+]>CO>[CH3:18][O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][C:9]([F:11])=[N:10][C:2]=1[F:1]참가 물질
6
실험 절차
To 2,6-difluoro-nicotinic acid (59, 5.60 g, 0.0352 mol) in methanol (60.0 mL) was added concentrated sulfuric acid (1.0 mL, 0.019 mol). The reaction was heated to reflux overnight, then poured into water, basified with 1M potassium carbonate to pH around 9, and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated to give a yellow oil (60, 3.5 g, 57.0%).
후처리
- temperatureThe reaction was heated
- temperatureto reflux overnight
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- concentrationconcentrated
- customto give a yellow oil (60, 3.5 g, 57.0%)
출처 및 근거
- ORD 기록
- ord-457d5bb45a014f8c8eb941300a3b354c
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08722702B2
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