Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1024194생성일: 2026년 10월 24일
Sodium hydride → (1H-pyrrolo[2,3-b]pyridin-3-yl)-[6-(3-trifluoromethyl-benzyloxy)-pyridin-3-yl]-methanone
https://huagongshe.com/ko/reaction/1024194
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-(Trifluoromethyl)benzylic alcohol | HCID 67681 | — |
| 반응물 | (6-Chloro-pyridin-3-yl)-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone | HCID 57588066 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | (1H-pyrrolo[2,3-b]pyridin-3-yl)-[6-(3-trifluoromethyl-benzyloxy)-pyridin-3-yl]-methanone | HCID 59593361 | — |
반응 단계
To (6-Chloro-pyridin-3-yl)-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone 7 in DMSO was added (3-trifluoromethyl-phenyl)-methanol 72. Sodium hydride was added and the reaction was heated to 60° C. for two hours. The reaction was quenched with water and extracted with ethyl acetate. The organic portion was dried with magnesium sulfate and concentrated to provide (1H-pyrrolo[2,3-b]pyridin-3-yl)-[6-(3-trifluoromethyl-benzyloxy)-pyridin-3-yl]-methanone 73, which was used in the next step without additional purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08722702B2 |
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| 출처 데이터셋 | uspto-grants-2014_05 |
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| ORD ID | ord-7593811251104b8d83f77363e00b04e7 |
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| 출처 메모 | uspto-grants-2014_05 |
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