Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → (6-Bromo-pyridazin-3-yl)-(4-chloro-benzyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 4-Chlorobenzaldehyde | HCID 7726 | — |
| 반응물 | Triethylsilane | HCID 12052 | — |
| 반응물 | 6-Bromopyridazin-3-amine | HCID 2794779 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (6-Bromo-pyridazin-3-yl)-(4-chloro-benzyl)-amine | HCID 57619288 | — |
반응 단계
To 6-bromo-pyridazin-3-ylamine (521, 0.85 g, 0.0049 mol) in acetonitrile (30.0 mL) were added 4-chlorobenzaldehyde (40, 0.82 g, 0.0058 mol), triethylsilane (4.0 mL, 0.025 mol) and trifluoroacetic acid (2.0 mL, 0.026 mol). The reaction was heated to reflux for 4 hours, then poured into water, and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated and washed with ethyl acetate to give a white solid (522, 1.0 g). MS (ESI) [M+H+]+=298.3, 300.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08722702B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-ccf63b55d30f4df48f622b0cd923c1d1 |
| 출처 메모 | uspto-grants-2014_05 |