1,1-Cyclohexanedicarbonitrile → [1-(Aminomethyl)cyclohexyl]methanamine
반응식
[C:1]1([C:9]#[N:10])([C:7]#[N:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOCC>[NH2:8][CH2:7][C:1]1([CH2:9][NH2:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
4
실험 절차
Cyclohexane-1,1-dicarbonitrile (20.0 g) was taken up in dry Et2O (70 mL). This mixture was added dropwise to a suspension of LiAlH4 (17.0 g) in dry Et2O (250 mL) cooled in an ice bath. The mixture was stirred overnight at room temperature, cooled in an ice bath, and quenched by adding H2O (17.0 mL), 2M aqueous NaOH (34.0 mL) and again H2O (17 mL). The suspension was filtered, the filter cake was washed with Et2O, and the combined filtrates were evaporated to dryness yielding 20.8 g of a clear, colorless liquid. 1H NMR (400 MHz, CDCl3) δ 1.05-1.55 (m, 14H), 2.61 (s, 4H).
후처리
- temperaturecooled in an ice bath
- temperaturecooled in an ice bath
- customquenched
- additionby adding H2O (17.0 mL), 2M aqueous NaOH (34.0 mL) and again H2O (17 mL)
- filtrationThe suspension was filtered
- washthe filter cake was washed with Et2O
- customthe combined filtrates were evaporated to dryness
- customyielding 20.8 g of a clear, colorless liquid
출처 및 근거
- ORD 기록
- ord-29bcc19f59174ca69225c1ba4463760d
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08722887B2
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