Potassium Cyanide → 1H-Indazole-5-carbonitrile

HRID 1024407노트

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HRID 1024407 반응식
Br[C:2]1[CH:3]=[C:4]2[CH:10]=[CH:9][N:8]([Si](C(C)(C)C)(C)C)[C:5]2=[N:6][CH:7]=1.[C-:18]#[N:19].[K+]>[Cu].[Pd].CN(C=O)C>[C:5]([C:4]1[CH:3]=[C:2]2[C:7](=[CH:9][CH:10]=1)[NH:6][N:19]=[CH:18]2)#[N:8]

참가 물질

6

반응물 2

HCID 9032Potassium CyanideHCID 497590181H-Pyrrolo[2,3-B]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-

생성물 1

HCID 111263841H-Indazole-5-carbonitrile

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 23978Copper촉매HCID 6228Dimethylformamide용매

실험 절차

Compound 19 can be cyanated with, for example, KCN in heating DMF in the presence of a catalyst such as, copper or palladium to provide the 5-cyano azaindole 46.

출처 및 근거

ORD 기록
ord-dcc98bf9435e4e029c865f2fca5b2c9c
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722889B2

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