4-Chloro-2-phenoxyphenyl isocyanate → Methyl 2-(5-(4-(3-(4-chloro-2-phenoxyphenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[C:4]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:3]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[O:29][C:28]([C:30]([NH:32][CH:33]([CH:38]([CH3:40])[CH3:39])[C:34]([O:36][CH3:37])=[O:35])=[O:31])=[N:27][CH:26]=2)=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:10])[NH:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[O:29][C:28]([C:30]([NH:32][CH:33]([CH:38]([CH3:40])[CH3:39])[C:34]([O:36][CH3:37])=[O:35])=[O:31])=[N:27][CH:26]=3)=[CH:21][CH:20]=2)=[C:4]([O:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:3]=1참가 물질
3
실험 절차
The title compound was synthesized analogous to Example 1, using 4-chloro-1-isocyanato-2-phenoxybenzene and intermediate 1. Yield 79%; 1HNMR (DMSO-d6, 300 MHz): δ 9.61 (s, 1H), 8.99 (d, 1H), 8.74 (s, 1H), 8.4 (d, 1H), 7.8 (s, 1H), 7.77 (d, 2H), 7.6 (d, 2H), 7.44 (d, 2H), 7.22 (dd, 1H), 7.1 (d, 2H), 7.0 (dd, 1H), 6.85 (d, 1H), 4.3, (m, 1H), 3.67 (s, 3H), 2.28 (m, 1H), 0.95 (d, 6H); MS (ES+): m/z 563 (M+1).
출처 및 근거
- ORD 기록
- ord-a0bfa7fd107d48b29ad09e39ae05940d
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08722901B2
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