Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorophenyl isocyanate → Methyl 2-(5-(4-(3-(2-chlorophenyl)ureido)phenyl)thiazole-2-carboxamido)-3-methylbutanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorophenyl isocyanate | HCID 76833 | — |
| 반응물 | Methyl 3-methyl-2-(5-(4-nitrophenyl)thiazole-2-carboxamido)butanoate | HCID 67150324 | — |
| 생성물 | Methyl 2-(5-(4-(3-(2-chlorophenyl)ureido)phenyl)thiazole-2-carboxamido)-3-methylbutanoate | HCID 52934365 | 87% |
반응 단계
The title compound was synthesized analogous to Example 9, using 1-chloro-2-isocyanatobenzene and intermediate 2. Yield: 87%; 1HNMR (DMSO-d6, 300 MHz): δ 9.67 (s, 1H), 8.74 (d, 1H), 8.38 (s, 1H), 8.36 (s, 1H), 8.15 (dd, 1H), 7.75 (d, 2H), 7.6 (d, 2H), 7.49 (dd, 1H), 7.32 (m, 1H), 7.06 (m, 1H), 4.33, (m, 1H), 3.68 (s, 3H), 2.26 (m, 1H), 0.95 (d, 6H); MS (ES+): m/z 487 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08722901B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-eff5040455484273aebb7c21b6c56f8d |
| 출처 메모 | uspto-grants-2014_05 |