4-Fluorophenol → 6-(4-Cyanophenoxy)-2-(4-fluorophenoxy)nicotinic acid ethyl ester

반응식

[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=2)=[N:7][C:6]=1Cl)[CH3:2].[F:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=2)=[N:7][C:6]=1[O:29][C:26]1[CH:27]=[CH:28][C:23]([F:22])=[CH:24][CH:25]=1)[CH3:2]

참가 물질

반응물 2

HCID 97324-Fluorophenol

HCID 86665953HCID 86665953, 화합물

생성물 1

HCID 676077006-(4-Cyanophenoxy)-2-(4-fluorophenoxy)nicotinic acid ethyl ester수율 75%

실험 절차

2-Chloro-6-(4-cyano phenoxy)nicotinic acid ethyl ester (0.25 g, 0.81 mmol) and 4-fluorophenol (0.09 g, 0.81 mmol) were coupled using the procedure of Example 17(b) to afford 0.23 g of the required product. Percentage purity (LCMS): 61.86%.

출처 및 근거

ORD 기록: ord-9b9e8f1a97ad40f69ed234e167c2d297
출처 데이터셋: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08722930B2

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